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МЕТАБОЛИТЫ КИНУРЕНИНОВОГО ПУТИ ОБМЕНА ТРИПТОФАНА В РАЗВИТИИ АНГИОПАТИЙ ПРИ САХАРНОМ ДИАБЕТЕ

МЕТАБОЛИТЫ КИНУРЕНИНОВОГО ПУТИ ОБМЕНА ТРИПТОФАНА В РАЗВИТИИ АНГИОПАТИЙ ПРИ САХАРНОМ ДИАБЕТЕ

Резюме

Название статьи	МЕТАБОЛИТЫ КИНУРЕНИНОВОГО ПУТИ ОБМЕНА ТРИПТОФАНА В РАЗВИТИИ АНГИОПАТИЙ ПРИ САХАРНОМ ДИАБЕТЕ
Title	KYNURENINE PATHWAY METABOLITES OF TRYPTOPHAN METABOLISM IN THE DEVELOPMENT OF ANGIOPATHIES DURING DIABETES MELLITUS
Категория	номер 2 за 2023 год (опубликован 10.07.2023)
Тип	Обзорная статья
Ключевые слова	триптофан, кинурениновый путь, сахарный диабет, ангиопатии
Keywords	tryptophan, kynurenine pathway, diabetes mellitus, angiopathy
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doi	10.52485/19986173_2023_2_173
УДК	616.379-008.64:577.112.387.4
Резюме	*Цель исследования.* Обзор современных сведений об участии промежуточных продуктов кинуренинового пути в патогенезе осложнений СД, а именно ангиопатий. *Материалы и методы.* Выполнен электронный поиск научной литературы в PubMed и Embase, опубликованной до марта 2023 года на предмет статей, в которых сообщалось об особенностях обмена триптофана (TRP), кинуренина (KYN), кинуреновой кислоты (KYNA), ксантуреновой кислоты (XA), антраниловой кислоты (AA) и хинолиновой кислоты (QA) в норме и при сахарном диабете (СД), особое внимание уделялось роли кинуренинов в развитии дисфункции эндотелия. *Результаты.* Описано влияние многих кинуренинов на углеводный обмен, свободнорадикальные процессы, иммунные реакции, раскрыта их роль в формировании некоторых патологий, в том числе таких, как метаболический синдром, сахарный диабет и его сосудистые осложнения. *Заключение.* Кинурениновый путь преобразования TRP выполняет несколько важных функций в организме, результаты исследований звеньев его течения постепенно выявляют сложные взаимоотношения между метаболическими нарушениями обмена триптофана, сахарным диабетом и сосудистыми осложнениями. Многие вопросы остаются неизученными, в представленном обзоре литературы намечены некоторые патогенетические взаимосвязи.
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Resume	*Objective.* To review current data about the participation of kynurenine pathway’s intermediate products in the pathogenesis of complications of diabetes, namely angiopathy. *Materials and methods.* There was an electronic research of the scientific literature in PubMed and Embase published up to March 2023 for articles that reported on the features of the metabolism of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), xanthurenic acid (XA), anthranilic acid (AA) and QUINoline acid (QA) in normal state and during diabetes mellitus (DM). Special attention was paid to the role of kynurenines in the development of endothelial dysfunction. *Results.* A descriptive research of the variety of kynurenines’ influence on carbohydrate metabolism, free radical processes, immune responses is described, as well as their role in the formation of some pathologies, including metabolic syndrome, diabetes mellitus and its vascular complications, is presented. *Conclusion.* The kynurenine pathway of TRP conversion performs several important functions in the body; the results of studies of its course features gradually reveal the complicated relationship between metabolic disorders of tryptophan metabolism, diabetes mellitus and vascular complications. Many issues remain unexplored; some pathogenetic relationships are outlined in currnet literature review.
Автор 1	Фефелова Елена Викторовна
Автор 2	Саклакова Ольга Алексеевна
Автор 3	Максименя Мария Владимировна
Автор 4	Коцюржинская Наталья Николаевна
Автор 5	Караваева Татьяна Михайловна
Автор 6	Терешков Павел Петрович